Celyad and the French company Cellectis, the first to run clinical trials with these off-the-shelf cells, are among these. These new and improved generations of CAR-T cell therapy are promising.
However, they are still in the early stages of clinical trials and will need a few years until they can reach the market. One of the first medical applications of this technology could be in cancer. Another trial with a similar approach is currently running in the US. The technology is still in its early stages, and there are concerns that the overall effects of using CRISPR in humans are not yet fully understood. But if these concerns are successfully addressed, the potential for cancer is big.
Trends in Cancer Research | CancerCare
In the last decade, researchers have uncovered that the human microbiome — the collection of microorganisms that live in our bodies — plays an important role in many aspects of our health. Including cancer. We also know that within the microbiome there are peptides that mimic antigens on the surface of tumors. These can be used to make the tumor visible to the immune system again. Enterome has created a cancer vaccine based on these tumor-mimicking molecules, which generates strong immune responses against the tumor.
In particular, Enterome aims to combine this technology with checkpoint inhibitors , a type of drug that blocks one of the mechanisms by which tumor cells hide from the immune system.
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Although the cancer vaccine has shown promise in preclinical studies, is still has not been tested in human trials. Advances in multiple fronts are increasingly making cancer a more manageable disease. With more options available, patients will be able to get therapies that are specific to their needs.
We can expect a future where we will have much more precise treatments based upon the genomic signature of the patient.
Most of these new technologies against cancer still have to prove their worth in clinical trials. Even in the best-case scenario, it will be several years until they are available.
However, we are on track to reach a future where cancer treatment is personalized and the chances of beating the disease are higher than ever. Images via Shutterstock. This article was originally published on October and has since been updated. Do you want to join 10 subscribers who receive the hottest biotech news in their inbox every Friday for free?
By accepting, you support our independent media and its' freely accessible content. Newsletter Subscription Do you want to join 10 subscribers who receive the hottest biotech news in their inbox every Friday for free? Hell Yeah. Many of these targeted agents are pills. Meanwhile, immune-oncology drugs—mainly antibodies that interfere with the PD-1 and PDL-1 receptor and ligand families—are used against a variety of tumors. That report reflects a trend, of increasing antibody use and less chemotherapy, that is revolutionizing treatment of lung cancer, melanoma, and other types of malignancy.
This problem is not going away.
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Some argue that anti-cancer medications should not necessarily be covered by private insurers, or by public insurers Medicare or Medicaid , unless the cancer treatments demonstrate a certain level of benefit to patients. This is a societal issue. The discussion reflects values and notions of personal responsibility for cancer care, and whether all people with malignant illness are deserving of equal opportunity to try the anti-cancer treatments they and their doctors think are most appropriate.
This is a crucial matter for patients with malignancy who wish to try novel cancer drugs and need to know if their tumors harbor molecular features that match those new drugs. In general, the debate concerns the quality of diagnostic tests, and costs.
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Doctors and patients need reliable and reproducible results. And so accreditation of labs that perform molecular testing becomes increasingly necessary as these tests becomes more relevant to everyday prescription of oncology drugs and clinical decisions. As things stand, payment for molecular testing of cancer has limited uptake of some very useful tests.
I will write more on this topic separately. In general, I see this as the future of oncology.
The next month, doctors at the annual big U. That medication is under review by the FDA; more will follow. Not all oncologists see merit, or feasibility, of this sort of approach to treating cancer. Evidently, neratinib demonstrated some and limited activity in patients with HER2 abnormalities with advanced breast, salivary, bile duct and a few other tumors, but not with colon cancer.